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KMID : 0352019930180020059
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Kyung Hee University Medical Journal
1993 Volume.18 No. 2 p.59 ~ p.68
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Effects of Lymphokine Activated Killer Cells and T Cells to Epstein-Barr Virus Infected cells
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항영호
유승민/조정제/호순태/하윤문
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Abstract
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In this study, the cytotoxic effects of the lymphokine activated killer (LAK) cells and T cells on the Epstein-Barr virus infected peripheral blood B lymphoblastoid cell lines were tested by 51Cr releasing methods. To induce the lymphokine
activated
liller cells, natural killer cells were treated with recombinant human interleukin 2 and cultured for 3 days. The cytotoxic effect of the LAK cells was higher than that of T T cells. The cytotoxicity of T cells was significantly diminished by
cyclosporin A, a potent immunosuppressive agent. The cytotoxic effect of T cells was decreased linearly until the concentration of cylclosporin A increased to 2 μg/ml. But above 2 ug/ml of cyclosporin A concentration, the cytotoxic effect was
not
decreased.
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KEYWORD
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